致力于高性能工业微生物菌种开发，推动秸秆等废弃生物质向生物燃料及高值化学品高效转化。以工业酿酒酵母为对象，聚焦秸秆 C5/C6 糖共代谢、抑制物耐受与环境胁迫瓶颈，开展机制解析和菌株创制，为酵母高效育种提供理论依据，为工业生产提供优质菌种资源。作为负责人主持国自然青年项目（C类）和企业合作项目等6项，申请/授权发明专利12项，以第一/通讯作者发表 SCI 论文 17 篇。

2009.09-2013.06，四川大学 制药工程，工学学士

2013.09-2019.06，四川大学 环境工程，工学博士

2021.07-至今，四川大学 环境科学与工程，专职博士后

2023.05-至今，四川大学 蒙特卡罗模拟器，副研究员（专职科研）

1. 国家自然科学基金青年项目（C类），2024.01-2026.12，主持

2. 企业横向项目，技术开发项目，2022.01-2025.12，主持

3. 企业横向项目，技术开发项目，2025.01-2027.12，主持

4. 生物基运输燃料技术全国重点实验室开放课题，2026.05-2027.04，主持

5. 后续能源材料与器件教育部工程研究中心（四川大学）创新引导课题，2025.01-2026.12，主持

6. 高校基本科研业务费，四川大学专职博士后研发基金项目，2022.01-2023.12，主持

[1] Rong-Rong Chen, Li Wang, Xue-Xue Ji, Cai-Yun Xie*, Yue-Qin Tang. Identification of key transcription factors, including DAL80 and CRZ1, involved in heat and ethanol tolerance in Saccharomyces cerevisiae. Biotechnol Biofuels Bioprod. 2025; 18, 50.

[2] Xin-Yu Xiao, Xin-Yu Wang, Ya-Jing Wu, Ying Cheng, Quan Zhang, Cai-Yun Xie*, Yue-Qin Tang*. Improving inhibitor tolerance of xylitol-producing Saccharomyces cerevisiae by overexpressing key target genes mined through comparative transcriptomes. Biotechnol Biofuels Bioprod. 2026; 19, 15.

[3] Xiu-Lin Chu, Xiang-Yu Peng, Zhao-Yong Sun*, Cai-Yun Xie*, Yue-Qin Tang. Converting kitchen waste into value-added fertilizer using thermophilic semi-continuous composting-biofiltration two-stage process with minimized NH3 emission. Bioresour Technol. 2024; 406:130955.

[4] Li Wang, Bo Li, Ran-Ran Su, Shi-Peng Wang, Zi-Yuan Xia, Cai-Yun Xie*, Yue-Qin Tang*. Screening novel genes by a comprehensive strategy to construct multiple stress-tolerant industrial Saccharomyces cerevisiae with prominent bioethanol production. Biotechnol Biofuels Bioprod. 2022; 15(1):11.

[5] Yu-Ping Xia, Xin-Yu Wang, Bai-Xue Yang, Cai-Yun Xie*, Yue-Qin Tang. Response mechanisms of xylitol-producing Saccharomyces cerevisiae strains to acetic acid and furfural and the role of SPI1, CTT1, and CLB1 in tolerance. Microb Cell Fact. 2026; 25, 114.

[6] Mao-Ting Li, Li Wang, Cai-Yun Xie*, Min Gou, Yue-Qin Tang. Transcriptomics-guided identification of engineering targets for improving salt tolerance in Saccharomyces cerevisiae. Microb Cell Fact. 2026; 25, 139.

[7] Xue-Xue Ji, Quan Zhang, Bai-Xue Yang, Qing-Ran Song, Zhao-Yong Sun, Cai-Yun Xie*, Yue-Qin Tang. Response mechanism of ethanol-tolerant Saccharomyces cerevisiae strain ES-42 to increased ethanol during continuous ethanol fermentation. Microb Cell Fact. 2025; 24, 33.

[8] Cai-Yun Xie, Ran-Ran Su, Bo Wu, Zhao-Yong Sun, Yue-Qin Tang*. Response mechanisms of different Saccharomyces cerevisiae strains to succinic acid. BMC Microbiol. 2024; 24(1):158.

[9] Xue-Xue Ji, Bo Li, Rong-Rong Chen, Zi-Yuan Xia, Cai-Yun Xie*, Yue-Qin Tang*. Impact of complex inhibitors in straw hydrolysates on xylose-fermenting Saccharomyces cerevisiae and inhibitor-tolerant strain construction. Fungal Biol. 2026; 130(1), 101709.

[10] Xin-Yu Xiao, Bo Li, Zi-Yuan Xia, Quan Zhang*, Cai-Yun Xie*, Yue-Qin Tang. Regulatory mechanism of Haa1p and Hap4p in Saccharomyces cerevisiae to mixed acetic acid and formic acid when fermenting mixed glucose and xylose. Microb Cell Fact. 2025; 24, 156.

[11] EnZhe Yang, Hong Wang, Lu Wang, ZiYuan Xia, CaiYun Xie*, Min Gou*, YueQin Tang, Multi-omics analysis unveils mechanisms underlying ARTP mutagenesis-induced enhancement of rhamnolipid production in Pseudomonas aeruginosa, Food Biosci. 2025; 68, 106597.

[12] Yajing Wu, Bo Li, Bu Miao*, Caiyun Xie*, Yue-Qin Tang. Saccharomyces cerevisiae employs complex regulation strategies to tolerate low pH stress during ethanol production. Microb Cell Fact. 2022; 21(1):247.

[13] Bo Li, Li Wang, Jin-Yu Xie, Zi-Yuan Xia, Cai-Yun Xie*, Yue-Qin Tang*. Regulatory mechanism of Haa1p and Tye7p in Saccharomyces cerevisiae when fermenting mixed glucose and xylose with or without inhibitors. Microb Cell Fact. 2022; 21(1):105.

[14] Furong Zuo, Yajing Wu, Yanqiu Sun, Caiyun Xie*, Yueqin Tang. Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression. Sci Rep. 2024; 14:22875.

[15] Lu Wang, Xinmin Song, Chuanfu Ji, Maozhang Tian, Caiyun Xie*, Min Gou*, Wenfeng Song, Yueqin Tang. Transcriptomic response of Xanthomonas campestris during xanthan gum production to glutamate concentration. Sci Rep. 2026; 16, 13377.

[16] Cai-Yun Xie, Bai-Xue Yang, Qing-Ran Song, Zi-Yuan Xia, Min Gou*, Yue-Qin Tang*. Different transcriptional responses of haploid and diploid S. cerevisiae strains to changes in cofactor preference of XR. Microb Cell Fact. 2020; 19(1):211.

[17] Cai-Yun Xie, Bai-Xue Yang, Ya-Jing Wu, Zi-Yuan Xia, Min Gou, Zhao-Yong Sun, Yue-Qin Tang*. Construction of industrial xylose-fermenting Saccharomyces cerevisiae strains through combined approaches. Process Biochem. 2020; 96:80-89.